RUVBL interacts with γTuRC subcomplexes but is not part of fully assembled γTuRC. Likewise, RUVBL assembles γTuRC from a minimal set of core subunits in a heterologous coexpression system. Here, we show that a complex of RuvB-like protein 1 (RUVBL1) and RUVBL2 “RUVBL” controls assembly and composition of γTuRC in human cells. Since its discovery over two decades ago, γTuRC has evaded in vitro reconstitution and thus detailed structure-function studies. The microtubule nucleator γ-tubulin ring complex (γTuRC) is essential for the function of microtubule organizing centers such as the centrosome.
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